A lot of blood sugar enters the bloodstream. The pancreas pumps out more insulin to get blood sugar into cells. Over time, cells stop responding to all that insulin—they've become insulin resistant.

Insulin resistance is a feature of type 2 diabetes, and it can be present with prediabetes. Insulin is essential for enabling the body to use glucose effectively and prevent blood sugar levels from rising too high. When insulin does not work effectively, blood sugar levels can rise, and diabetes can develop.
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Study :
https://www.annualreviews.org/....doi/pdf/10.1146/annu
https://www.nejm.org/doi/pdf/1....0.1056/NEJMoa0806470
https://www.nejm.org/doi/pdf/1....0.1056/NEJMoa0802743
https://www.acc.org/latest-in-....cardiology/clinical-