The tenth season of the reality/sports competition series American Ninja Warrior premiered on May 30, 2018 on NBC. Hosts Matt Iseman and Akbar Gbaja-Biamila returned for their ninth and sixth seasons, respectively, alongside sideline reporter Kristine Leahy who returns for her fourth. Prior to the season premiere, NBC aired two special episodes. On May 17, 2018, a two-hour All-Stars special aired, while on May 24, 2018, the second annual Celebrity Ninja Warrior for Red Nose Day featured celebrities raising money for charity.

Changes this season included the introduction of the 18-foot (5.5 m) "Mega Wall". It was next to the original 14'6" (4.4 m) warped wall, and gave competitors the choice of which to climb. Competitors who chose the Mega Wall had only one attempt to reach the top, and if successful, would win $10,000. If unsuccessful, the competitor would only get one shot at the warped wall. Those who did not wish to attempt the Mega Wall had three chances to reach the top of the warped wall. The Mega Wall was only in play during the city qualifiers. In addition, the age limit was lowered down from 21 in all previous seasons to 19 this season. The "Last Ninja Standing", the competitor who goes the farthest in the finals, if no one completes stage 4, would now receive $100,000.

Season 7 champion Isaac Caldiero participated and finished the Indianapolis qualifiers, marking his return to competition in the series. He would later fall in the city finals, marking the end of his season as he fell at Block Run.