Smith Gemini

@602d091b1

Subscribers

The first evidence of human B2M was found in the urine of renal tubular disease patients. Twelve kDa is its molecular weight. It was later discovered in every bodily fluid. The majority of nucleated cells produce the 99-amino acid residue protein, which is a membrane protein that makes up the class I HLA molecule's constant light chain. Its structure is quite similar to the immunoglobulin molecule's constant section, specifically the C3H domain. It is found on the surface of lymphocytes both as a free molecule and as a component of the HLA antigen complex. B2M is released into the bloodstream, most likely as a result of cell death or membrane turnover.