Architectural Digest visits actors Neil Patrick Harris and David Burtka at their townhouse in Harlem.

A Jonathan Adler light fixture crowns the living room, where Room & Board sofas are grouped with a high-back chair designed by Powell & Bonnell for Dennis Miller Assoc., Arteriors nesting tables, and a bespoke Trace Lehnhoff cocktail table.

The parlor floor’s central hall features a vintage Venini light fixture and (atop pedestals) sculptures by Tom LaDuke; works by Ed Templeton are arranged along the staircase.

In the music room, walls clad in a Donghia fabric serve as a backdrop for a large Annie Lapin painting, which overlooks a Yamaha player piano and a Bourgeois Bohème Atelier chaise longue.

Holly Hunt pendant lights are suspended above the Caesarstone-top island in the kitchen, which is equipped with a Wolf range and hood.

Furnished for entertaining, the parlor-floor salon is outfitted with a bar that was salvaged from a Connecticut hotel and acquired from the Demolition Depot/Irreplaceable Artifacts; the chandelier is by Carolina Fontoura Alzaga, and the artworks are by Ed Ruscha, Ahmed Alsoudani, and Francesca Gabbiani.

The walls of the den are covered in an Andrew Martin wallpaper and decorated with colorful magic memorabilia; the guitars are by Gibson and Jean Larrivée Guitars, the vintage desk and chair are from Arte de Mexico, and the sofa is by RH.

A wall covering by Calico Wallpaper adds intrigue to the master bedroom, where a Jason Miller light fixture from Design Within Reach hangs above the custom-made bed, which is upholstered in a Rose Tarlow Melrose House fabric.

Anchored by an RH Baby & Child bunk bed, Gideon’s room is enlivened by a Flash Gordon lithograph and a Keith Haring chair by Vilac; the Roman shade is of a DwellStudio fabric for Robert Allen, and the carpet is by Safavieh.

The master bath’s shower fittings and tub are by Kallista, and the tiles on the tub surround, walls, and floor—as well as the python-patterned mirrored tile—are by Ann Sacks.

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Inside Neil Patrick Harris's Home That Has a Secret Magic Office | Architectural Digest