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Resistance: Fall of Man is a 2006 science-fiction horror first-person shooter video game for the PlayStation 3. It was developed by Insomniac Games and published by Sony Computer Entertainment. The game is set in an alternate history 1951, and follows Sergeant Nathan Hale as he and the human resistance forces attempt to drive a mysterious alien-like invasion out of Britain. The story continues in its sequel Resistance 2.

The game was originally developed under the title I-8, as it was the eighth title to be in production by Insomniac Games. It was released as a PlayStation 3 launch title in Japan on November 11, 2006, in the United States on November 17, 2006 and in Europe on March 23, 2007. Resistance had positive critical reception, garnering particular praise in view of its status as a launch title and winning several awards, as well as being the first PlayStation 3 game to sell over one million copies, followed immediately by MotorStorm.

Sony and Insomniac Games have since become embattled with the Church of England for using interior shots of Manchester Cathedral to recreate the building within the game, as well as "promoting violence" within the building. Resistance was Insomniac's first game to receive M for Mature by the ESRB.

The game, along with its sequels Resistance 2 and Resistance 3 shut down its online servers on April 8, 2014.