Dr. Roger Seheult of http://www.medcram.com illustrates the key differences between the various types of penicillin antibiotic medications:

0:57 - Discovery and brief history of penicillin
1:44 - Penicillinase
2:00 - Semi-synthetic penicillins (methicillin, oxacillin, nafcillin)
3:21 - Need for gram negative antibiotic coverage (E-coli, pseudomonas, etc.)
4:26 - Aminopenicillins (ampicillin, amoxicillin)
4:49 - Extended spectrum penicillin (piperacillin, ticarcillin)
5:14 - Beta-lactamase
5:42 - Beta-lactamase inhibitors (ampicillin/sulbactam and amoxicillin/clavulanic acid
6:35 - Piperacillin/tazobactam
6:54 - Ticarcillin and clavulanate
8:18 - Staph aureus and mutations against penicillin (PCN)
8:42 - MRSA - methicillin-resistant staphylococcus aureus
9:14 - Clindamycin, trimethoprim and sulfamethoxazole, quinolones, vancomycin, daptomycin, and linezolid
10:13 - A note about cross-reactivity / low platelets
10:33 - MSSA and nafcillin


Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.

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Produced by Kyle Allred PA-C

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