Gout may be triggered by an increasing level of uric acid in our body. It guarantees an intense pain usually at the big toe joints and is more likely to flare at night (approximately 2.4 times more frequent than the daytime). This is because the concentration of uric acid increases while we're sleeping. While asleep, through breathing and sweating, our body loses moisture. Less water content in the blood equals higher concentration of uric acid and may lead to hyperuricemia, the precursor to gout.

Holding our breath while sleeping is out of the option so the other factor that we can control to manage our uric acid level is through diet. Avoid eating a diet rich in red meat and seafood with high purine content. It's also highly risky to consume alcohol and beverages sweetened with fruit sugar. Further treatment includes several types of drugs that can block the uric acid production such as Allopurinol and Febuxostat.

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REFERENCES:
Purines made in the body
https://www.sciencedirect.com/....science/article/pii/
Extra urate is flushed out through urine
https://www.uofmhealth.org/health-library/aa15402
Foods with high purine content
https://www.medicalnewstoday.com/articles/322590
Gout Diet
https://www.mayoclinic.org/hea....lthy-lifestyle/nutri
General
https://www.cdc.gov/arthritis/basics/gout.html
https://www.niams.nih.gov/health-topics/gout
https://www.nhs.uk/conditions/gout/
https://my.clevelandclinic.org..../health/diseases/475

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